The Greatest Guide To PP88
The Greatest Guide To PP88
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23. A nucleic acid vector for use in in vivo delivery of the nucleic acid of interest into a targeted receiver bacterial mobile, stated nucleic acid of desire developing a presented effect on claimed qualified receiver bacterial mobile, wherein claimed vector comprises: stated nucleic acid of interest, and
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during the context of the invention, explained provided outcome may very well be selected from your group consisting of killing the receiver bacterial cell, earning the receiver bacterial cell stop generating a provided molecule, earning the receiver bacterial cells reducing its degree of production of a presented molecule, and making the receiver bacterial mobile create a molecule of fascination.
In the method from the present creation, a nucleic acid of desire is shipped right into a targeted receiver bacterial mobile of stated microbiome or a group of specific receiver bacterial cells of said microbiome, claimed nucleic acid of interest staying comprised in a very vector supplied by a 立即參與賭局 donor bacterial mobile.
The present inventors without a doubt created herein a selected conditional origin of replication derived from PICIs.
In a certain embodiment, the subject has not acquired any treatment method prior to the administration of the vectors in accordance with the creation, specially a vector packaged into a delivery motor vehicle according to the invention, ideally a packaged plasmid or phagemid right into a bacterial virus particle according to the invention, or of a pharmaceutical or veterinary composition in accordance with the creation.
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“Cas9” can Therefore denote a modified protein, as an example truncated to get rid of domains of the protein that are not essential for the predefined capabilities of the protein, especially the domains that aren't needed for conversation Together with the gRNA(s).
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fourteen. the tactic In accordance with Anybody of embodiments 1 to 13, wherein the conditional origin of replication is undoubtedly an origin of replication, the replication of which depends on the existence of the provided protein, peptid, nucleic acid, RNA, molecule or any combination thereof.
for a Management for unspecific killing, packaged phagemids had been also transduced in to the pressure s11983, which can be a spinoff of the O157 H10dstx strain missing the lacZ gene.
As applied herein, the term “conjugative plasmid” refers to a plasmid that's transferred from a single bacterial mobile to a different during conjugation as well as a “donor bacterium”, as utilised herein, is then a bacterium that is definitely effective at transferring a conjugative plasmid to another bacterium.
140、根据本公开的感兴趣的核酸可包含编码cas蛋白的核酸序列。多种crispr酶可用于用作质粒上感兴趣的序列。在一些实施方案中，crispr酶为ii型crispr酶。在一些实施方案中，crispr酶催化dna切割。在一些其他实施方案中，crispr酶催化rna切割。优选地，crispr酶不造成双链断裂。在一些实施方案中，crispr酶造成单链断裂或切口。在一些实施方案中，crispr酶不会在dna或rna中造成任何断裂。在一个实施方案中，cas13-脱氨酶融合被用于对rna进行碱基编辑。
本发明涉及用于调节宿主微生物组的感兴趣的核酸，涉及编码所述核酸的载体以及涉及用于通过递送所述感兴趣的核酸来调节宿主微生物组的方法。
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